2) Alopecia is induced by several factors such as decreased fibroblast follicle cell growth and renewal, increased dihydrotestosterone (DHT), and chemotherapy. Approximately 90% of hair is in anagen phase. The hair growth cycle consists of three phases namely anagen, catagen, and telogen, which represent the growing phase, involution phase, and resting phase, respectively. 1) Autoimmune diseases such as thyroid disease, diabetes mellitus, and rheumatoid arthritis are comorbidities associated with alopecia areata. A recent comorbidity study among patients with diagnosed alopecia shows that 74.1% of the patients have inflammatory diseases like atopy and contact dermatitis and mental health problems are seen in 25.5%. Inflammation to the scalp is linked to hair loss. Hair loss is mostly induced by genetic factors but stress also plays an important role these days, especially in young people including women. The incidence of hair loss has rapidly increased worldwide. Hair is considered one of the most important features of appearance and hair loss can therefore negatively impact self-esteem and damage overall quality of life. In conclusion, bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter. Moreover, bee venom stimulated proliferation of hDPCs and several growth factors (insulin-like growth factor 1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)2 and 7) in bee venom-treated hDPCs dose dependently compared with the control group. Bee venom inhibited the expression of SRD5A2, which encodes a type II 5α-reductase that plays a major role in the conversion of testosterone into dihydrotestosterone. In both anagen phase mice and dexamethasone-induced catagen phase mice, hair growth was increased dose dependently compared with controls. Bee venom promoted hair growth and inhibited transition from the anagen to catagen phase. Growth factors responsible for hair growth were analyzed by quantitative real-time PCR and Western blot analysis using mice skins and human dermal papilla cells (hDPCs).
#BEE STING TREATMENT SAN DIEGO CA SKIN#
In this study, we investigated the preventive effect of bee venom on alopecia, which was measured by applying bee venom (0.001, 0.005, 0.01%) or minoxidil (2%) as a positive control to the dorsal skin of female C57BL/6 mice for 19 d. Recent studies show that bee venom can be used to treat certain diseases including rheumatoid arthritis, neuralgia, and multiple sclerosis. Alopecia is an important issue that can occur in people of all ages.
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